Abstract Dense single nucleotide polymorphism (SNP) panels are widely used for genome-wide association studies (GWAS).In these panels, SNPs within a genomic segment tend to be highly correlated.Thus, association ORG CORNMEAL MEDIUM studies based on testing the significance of single SNPs are not very effective, and genomic-window based tests have been proposed to address this problem.However, when the SNP density on the genotype panel is not homogeneous, genomic-window based tests can lead to the detection of spurious associations by declaring effects of genomic windows that explain a large proportion of genetic variance as significant.We BIO C-GEL 500MG propose two methods to solve this problem.